Combination therapy with remdesivir and immunomodulators improves respiratory status in COVID-19: A retrospective studyArticle Published on 2022-12-012022-11-15 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 치료제, [키워드] 95% confidence interval Analysis Baricitinib baseline benefit body mass index combination therapy Concomitant contributed control group coronavirus disease COVID-19 COVID-19 patient COVID-19 patients Day Diabetes Mellitus examined faster greater hazard ratio immunomodulator immunomodulators IMPROVE in both group independent investigated median outcome Oxygen administration Patient patients Prognostic factors Remdesivir respiratory recovery retrospective Retrospective study severity single-center study standard treatment supplemental oxygen survival synergistic therapy Tocilizumab tocilizumab. treated two group [DOI] 10.1002/jmv.28037 PMC 바로가기
Severity predictors of COVID-19 in SARS-CoV-2 variant, delta and omicron period; single center studyArticle Published on 2022-10-252022-11-16 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome Analysis analyzed Appropriate BMI body mass index cause caused changes in Characteristics city Comorbidities coronavirus coronavirus disease COVID-19 COVID-19 severity cut-off value Dyspnea groups Hospitalization laboratory data LDH management moderate Moderate COVID-19 multiple logistic regression Omicron variant outcome Patient predictor progression renal dysfunction SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants sensitivity severe COVID-19 Sex significant difference significantly single center smoking sore throat specificity Symptoms the disease time Treatment treatment regimens two group university vaccination variant Yokohama [DOI] 10.1371/journal.pone.0273134 PMC 바로가기
Circulating tumor necrosis factor receptors are associated with mortality and disease severity in COVID-19 patientsArticle Published on 2022-10-112022-11-15 Journal: PLoS ONE [Category] 바이오마커, [키워드] addition age Biomarker body mass index C-reactive protein Chronic kidney disease CKD conducted coronavirus disease COVID-19 COVID-19 patient COVID-19 patients CRP CRP level D-dimer demonstrated diabetes discharged disease severity enrolled enzyme-linked immunosorbent examined glomerular filtration rate Hospitalization hospitalized patient Hyperinflammatory hypertension ICU ICU patient IL-6 influence intensive care Lactate Logistic regression analysis lymphocyte counts male males median Mortality multivariate Necrosis parameters Patient patients died patients with COVID-19 Prognosis receive receptor reported Retrospective study Serum level severity Significant significantly higher the patient TNF TNFR1 TNFR2 Treatment university utility were measured White blood cells [DOI] 10.1371/journal.pone.0275745 PMC 바로가기
Thrombosis risk assessment in patients with congenital thrombophilia during COVID – 19 infectionResearch article Published on 2022-10-012022-10-05 Journal: Thrombosis research [Category] 변종, 유전자 메커니즘, 진단, [키워드] absence ACAnticoagulants addition adjusted age Anticoagulant Anticoagulants Antithrombin Antithrombotic association ATAntithrombin BMIbody mass index body mass index case-control study changes in clinical picture Comorbidities Comorbidity comparable Computed tomography Confirmed COVID-19 infection contribute Corona Virus Disease COVID COVID-19 COVID-19 infection COVID-19 patient COVID-19 patients COVIDCorona Virus Disease Critical CTComputed Tomography D-dimer D-dimer level Deep venous thrombosis Diagnosis Direct oral anticoagulant disease DOACDirect Oral Anticoagulant DVTDeep Venous Thrombosis dysfunction evaluate Factor V Leiden factor VIII FEUFibrinogen Equivalent Fibrinogen Equivalent FII G20210AProthrombin mutation Final FV LeidenFactor V Leiden FVIII FVIIIFactor VIII genetic defect HBSHeparin Binding Site Heparin Binding Site individual Infection LMWHlow molecular weight heparin low molecular weight heparin Mild Odds ratio OROdds Ratio outcome parameter Patient patient group PCR/RFLPpolymerase chain reaction/restriction fragment length polymorphism PEPulmonary Embolism polymerase chain reaction/restriction fragment length polymorphism Prophylaxis Prothrombin mutation Pulmonary embolism receive Result risk risk of COVID-19 serious complication severe COVID-19 significantly significantly increased symptomatic thrombosis thrombotic thrombotic complication thrombotic event Thrombotic events Treatment Unusual Thrombosis UTUnusual Thrombosis Venous Thromboembolism vitamin K antagonist VKAVitamin K antagonist VTEVenous Thromboembolism was performed [DOI] 10.1016/j.thromres.2022.08.020 [Article Type] Research article
Epigenetic mechanisms and host factors impact ACE2 gene expression: Implications in COVID-19 susceptibilityResearch article Published on 2022-10-012022-10-05 Journal: Infection, genetics and evolution : journal of mol [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] ACE2 gene ACE2 protein age angiotensin-converting enzyme 2 Arterial hypertension association Asthma BMI body mass index changes in clinical variable clinical variables COVID-19 COVID-19 susceptibility described determinant disease susceptibility DNA methylation Epigenetic epigenetics evaluate evaluated expression expression profile Factor Host host cell host factors Infection involved Male sex mechanism Methylation molecular cause mRNA expression nasopharyngeal swab sample obesity overexpression Peripheral blood promoter region quantified regulated Result risk factor RT-qPCR SARS-CoV-2 SARS-COV-2 infection Sex significant difference smoking study group susceptibility the disease type II diabete underlying disease Variability variable virus volunteers was determined [DOI] 10.1016/j.meegid.2022.105357 [Article Type] Research article
Changes in Care during the COVID-19 Pandemic for People with Cystic FibrosisArticle Published on 2022-10-012022-11-16 Journal: Annals of the American Thoracic Society [Category] 변종, [키워드] 95% CI 95% confidence interval age Ambulatory care BMI body mass index calculated Care change changed changes in children coronavirus disease COVID-19 COVID-19 pandemic Cystic cystic fibrosis effective eligible enrolled expiratory FEV foundation Lung function no difference Paired t test pandemic predicted proportion pulmonary exacerbation Pulmonary function pulmonary function. registry risk severe disease the mean transitioned transmembrane Volume [DOI] 10.1513/AnnalsATS.202105-532OC PMC 바로가기
The Association of Baseline Plasma SARS-CoV-2 Nucleocapsid Antigen Level and Outcomes in Patients Hospitalized With COVID-19Article Published on 2022-10-012022-11-16 Journal: Annals of internal medicine [Category] COVID19(2023년), SARS, 변종, [키워드] 95% CI acute SARS-CoV-2 infection antibody Antigen baseline Biomarker body mass index Characteristics Clinical outcome clinically COVID-19 cross-sectional study delta variant discharge elevated ENhance enrolled Enrollment evaluate evaluated Factor Government greater higher odd hospital Hospital admission hospital discharge Hospitalized hospitalized patient hospitalized patients identify immunocompromising condition Infectious diseases Inpatient Laboratory less Level Logistic regression Male sex median Multiple multivariable N antigen nasal nasal swab Noninvasive ventilation Odds ratio operation outcome outcomes participant pathogenesis of COVID-19 pathogenesis of SARS-CoV-2 Patient patients with COVID-19 plasma Platform trial point-of-care polymerase chain predict quantification regression models Remdesivir renal impairment SARS-CoV-2 SARS-CoV-2 nucleocapsid severity speed Support Symptoms Therapeutics transcriptase viral replication was determined was measured were assessed worsened worsening [DOI] 10.7326/M22-0924 PMC 바로가기
COVID-19, obesity, and immune response 2 years after the pandemic: A timeline of scientific advancesArticle Published on 2022-10-012022-11-16 Journal: Obesity Reviews [Category] COVID19(2023년), SARS, 변종, [키워드] Adiposity body mass index C-reactive protein COVID-19 COVID-19 pandemic described explain expressed immune immune dysregulation immune response individual Inflammatory inflammatory markers inquiry mechanism obesity pathophysiology patients patients with obesity pharmacological treatments poor prognosis progressed researcher SARS-CoV-2 Science scientific advances. the disease vaccination variants [DOI] 10.1111/obr.13496 PMC 바로가기
Thromboembolic events in deceased patients with proven SARS-CoV-2 infection: Frequency, characteristics and risk factorsArticle Published on 2022-10-012023-07-10 Journal: Thrombosis research [Category] COVID19(2023년), [키워드] Autopsy body mass index COVID-19 Hereditary thrombophilia intensive care unit thromboembolism. [DOI] 10.1016/j.thromres.2022.08.021 PMC 바로가기
Effectiveness of prone position in acute respiratory distress syndrome and moderating factors of obesity class and treatment durations for COVID-19 patients: A meta-analysisResearch article Published on 2022-10-012022-10-05 Journal: Intensive & critical care nursing [Category] COVID19(2023년), SARS, 치료법, [키워드] 95% CI 95%CI acute respiratory distress acute respiratory distress syndrome Analysis article body mass index calculated CINAHL conducted coronavirus 2 COVID-19 COVID-19 patient effect size Effectiveness eligible experimental design Factor Final Invasive mechanical ventilation mean difference Meta-analysis methodology NCBI non-invasive ventilation obesity objective oxygen saturation PaO2 paO2/fiO2 Patient patients patients with COVID-19 prone Prone position prone positioning ProQuest Respiratory failure Result SARS-CoV-2 secondary outcome significantly SpO2 statistically significant syndrome Treatment Web of Science [DOI] 10.1016/j.iccn.2022.103257 [Article Type] Research article